Some useful navigation key bindings in Clojure-mode, actually any Lisp code editing mode in Emacs, are as follows:

Keybinding	Command
C-M-f	forward-sexp
C-M-b	backward-sexp
C-M-a	beginning-of-defun
C-M-e	end-of-defun
C-M-x	slime-compile-defun
C-x C-e	slime-eval-last-expression

Some of these key bindings get redefined when a buffer is in slime-mode to SLIME enhanced equivalents, but mostly they behave the same.

And, don't forget the exponential effect of the C-u prefix key.

Some other key bindings that are also useful are:

Keybinding	Command	Doc
C-M-q	indent-sexp	A lot of times when copying and pasting or otherwise modifying large blocks of s-expressions, the indentation of the code can get out of whack. indent-sexp can help restore the balance.
C-M-h	mark-defun
C-M-k	kill-sexp

Also worth knowing, the magic of dynamic abbrevs bound to the M-/ key binding. Dynamic abbrevs are a quick way to complete a long function or var name from a minimal prefix. It's very brute force (i.e, just searches for a match in all the open buffers), but since it's very fast, it comes in handy when you're working with partially evaluated Clojure code.

Everything begins with a Clojure instance which has SWANK loaded. Again, there are lots of ways of starting one of these, and the most common use case is with a Leiningen project setup. Setting up Leiningen is beyond the scope of this post, but the docs on Leiningen's github page are quite helpful in getting you started.

Once Leiningen is setup and you have a project.clj file for your project, you can invoke clojure-jack-in.

Once SLIME is connected, it's helpful to know the following commands:

Keybinding	Command	Doc
	slime-repl	This is a quick way to jump to the *slime-repl clojure* buffer.
	slime-reset	When your SLIME connection goes out of whack.
C-M-i	slime-complete-symbol
C-x e	slime-eval-last-expression	Makes every Clojure buffer into a REPL. Plus, it is very handy when iterating on tests.
C-c C-c, C-M-x	slime-compile-defun	This is convenient for compiling a defn or other top-level form, without having to put the cursor at the end of the expression.
	slime-list-connections	If you find yourself having to connect to multiple SWANK servers this command is helpful in switching between them.
	slime-list-threads	Show the list of scheduled JVM threads, and can provides an interactive way to kill running threads. Use with caution.